Ottaiano Alessandro, De Chiara Anna, Fazioli Flavio, Talamanca Annarita Aiello, Mori Stefano, Botti Gerardo, Milano Amalia, Apice Gaetano
Division of Immunology, National Cancer Institute, G. Pascale Foundation, via Mariano Semmola, 80131, Naples, Italy.
Anticancer Res. 2005 Nov-Dec;25(6C):4519-26.
Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, SYT-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.
成人软组织肉瘤（STS）是一组罕见的、高度异质性的肿瘤，起源于不同组织。它们具有局部侵袭性，可导致复发和远处转移。最常见的转移部位是肺、淋巴结、肝、骨和软组织。STS的分期基于一些预后信息：分级（低级别与中/高级别）、大小（小肿瘤与大肿瘤）、浸润深度（浅表肿瘤与深部肿瘤）以及是否存在远处转移。在过去10年中，大量新的标志物（增殖标志物和DNA改变、P-糖蛋白、p53、TLS-CHOP、细胞周期蛋白、生存素、端粒酶逆转录酶、PAX3-PAX7/FKHR、SYT-SSX1/2、血管内皮生长因子、E-钙黏蛋白和β-连环蛋白、nm23、SKP-2、p27、CD40）已被研究，涉及它们在促进进展（在实验室环境中）以及随后确定预后和治疗（在临床环境中）方面的作用。在本次调查中，我们聚焦于新的生物学预后因素在STS中的作用，并通过一份专门设计的问卷报告了此类研究的质量。
