Ajaiyeoba Ayotunde
Department of Ophthalmology, University College Hospital, Ibadan, Nigeria.
J Natl Med Assoc. 2005 Nov;97(11):1529-32.
The study aimed at finding out any association between vernal keratoconjunctivitis (VKC) and intestinal worm infestations in black children in Nigeria. This is a report of a case-control study of a total of 117 cases of VKC and 198 controls, who were newly presenting to two hospitals in Ibadan. The controls were comparable to the cases in many respects. While 67 (57%) of cases admitted to previous passage of worms, 59 (50.5%) children actually had parasitic infestations. Of these 59 children, 30 (51%) were due to roundworm, 12 (20%) to hookworm, 14 (24%) to protozoal infestation and others, e.g., tapeworms, 13 (5%). Among controls, 36.8% had parasitic infestation, out of which roundworms were responsible for 11.6%, hookworms 7.6%, protozoa 14.1% and others 3.5%. Children with VKC have almost twice (odds ratio = 1.68) the risk of having been infested by worms. Both older age in children and roundworm infestation were not independent risk factors for VKC. There was no significant association among all ages, sex, hookworm and other worms with VKC. Deworming may prove beneficial for children with VKC; however, more studies with appropriate design are required to prove this.
该研究旨在查明尼日利亚黑人儿童春季角结膜炎（VKC）与肠道蠕虫感染之间是否存在关联。这是一项病例对照研究的报告，共纳入了117例VKC病例和198名对照，这些病例和对照均为首次前往伊巴丹的两家医院就诊。对照在许多方面与病例具有可比性。67例（57%）病例承认曾有排虫史，而实际上有59名（50.5%）儿童存在寄生虫感染。在这59名儿童中，30名（51%）为蛔虫感染，12名（20%）为钩虫感染，14名（24%）为原生动物感染，其他如绦虫感染占13名（5%）。在对照中，36.8%存在寄生虫感染，其中蛔虫感染占11.6%，钩虫感染占7.6%，原生动物感染占14.1%，其他占3.5%。患有VKC的儿童感染蠕虫的风险几乎是（优势比 = 1.68）两倍。儿童年龄较大和蛔虫感染均不是VKC的独立危险因素。所有年龄、性别、钩虫及其他蠕虫与VKC之间均无显著关联。驱虫可能对患有VKC的儿童有益；然而，需要更多设计合理的研究来证实这一点。
