Iskra Bosiljka, Zivko Marijana, Kes Petar
Interni odjel, Opća bolnica Virovitica, Virovitica, Hrvatska.
Acta Med Croatica. 2005;59(4):325-8.
Myopathy and rhabdomyolysis are rare adverse effects of treatment with hydroxymethylglutaryl-coA reductase inhibitors. The risk of adverse effects is increased with the concomitant use of statin and specific drugs that can induce myopathy, in patients with liver and renal function impairment, hypothyroidism and diabetes mellitus. The clinical picture of rhabdymyolysis with acute renal failure caused by the use of simvastatin in a 54-year-old patient with diabetes mellitus and hypertension is described.
肌病和横纹肌溶解是羟甲基戊二酰辅酶A还原酶抑制剂治疗罕见的不良反应。在肝功能和肾功能损害、甲状腺功能减退和糖尿病患者中，同时使用他汀类药物和可诱发肌病的特定药物会增加不良反应的风险。本文描述了一名54岁患有糖尿病和高血压的患者因使用辛伐他汀导致横纹肌溶解伴急性肾衰竭的临床表现。
