Robinson Neil, Castella Vincent, Saudan Christophe, Sottas Pierre-Edouard, Schweizer Carine, Dimo-Simonin Noelle, Mangin Patrice, Saugy Martial
Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, rue du Bugnon 21, 1005 Lausanne, Switzerland.
Forensic Sci Int. 2006 Nov 10;163(1-2):148-51. doi: 10.1016/j.forsciint.2005.11.005. Epub 2005 Dec 6.
The case of seven urine samples collected for anti-doping purposes during a cycling stage race with moderately elevated testosterone and epitestosterone ratio (T/E) is reported. The very low probability of having all seven urine samples with such similar elevated T/E ratio (from 3.2 to 4.7) was very suspicious. Different pattern classification tools were tested to categorize the most similar steroid profiles, but none of the models enabled a clear classification of the different urine samples. Subsequently, genetic profiling of all urine samples was performed and demonstrated that three of the seven samples were collected from the same cyclist. Finally, the International Federation confirmed DNA profiling results. This suggests that urinary steroid data using several methodologies are not appropriate for identification purposes and to an extent not unique to individuals.
本文报告了在一场自行车阶段赛中为反兴奋剂目的采集的7份尿液样本的案例，这些样本的睾酮和表睾酮比值（T/E）中度升高。所有7份尿液样本都具有如此相似的升高T/E比值（从3.2到4.7）的极低概率非常可疑。测试了不同的模式分类工具以对最相似的类固醇谱进行分类，但没有一个模型能够对不同的尿液样本进行明确分类。随后，对所有尿液样本进行了基因分析，结果表明7份样本中的3份是从同一名自行车运动员身上采集的。最后，国际自行车联盟确认了DNA分析结果。这表明使用多种方法获得的尿液类固醇数据不适用于身份识别目的，且在一定程度上并非个体所特有。
