de Souza Lorena Brito, Ambudkar Indu S
Secretory Physiology Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States.
Cell Calcium. 2014 Aug;56(2):43-50. doi: 10.1016/j.ceca.2014.05.001. Epub 2014 May 26.
TRPC channels are Ca(2+)-permeable cation channels which are regulated downstream from receptor-coupled PIP2 hydrolysis. These channels contribute to a wide variety of cellular functions. Loss or gain of channel function has been associated with dysfunction and aberrant physiology. TRPC channel functions are influenced by their physical and functional interactions with numerous proteins that determine their regulation, scaffolding, trafficking, as well as their effects on the downstream cellular processes. Such interactions also compartmentalize the Ca(2+) signals arising from TRPC channels. A large number of studies demonstrate that trafficking is a critical mode by which plasma membrane localization and surface expression of TRPC channels are regulated. This review will provide an overview of intracellular trafficking pathways as well as discuss the current state of knowledge regarding the mechanisms and components involved in trafficking of the seven members of the TRPC family (TRPC1-TRPC7).
瞬时受体电位通道（TRPC）是钙离子通透的阳离子通道，其受受体偶联的磷脂酰肌醇-4,5-二磷酸（PIP2）水解的下游调节。这些通道参与多种细胞功能。通道功能的丧失或增强与功能障碍和异常生理状态有关。TRPC通道的功能受其与众多蛋白质的物理和功能相互作用的影响，这些相互作用决定了它们的调节、支架作用、转运，以及它们对下游细胞过程的影响。这种相互作用还使TRPC通道产生的钙离子信号分隔化。大量研究表明，转运是调节TRPC通道质膜定位和表面表达的关键方式。本综述将概述细胞内转运途径，并讨论有关TRPC家族七个成员（TRPC1 - TRPC7）转运所涉及的机制和成分的当前知识状态。
