Department of Integrative Physiology and Cardiovascular Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Exp Biol Med (Maywood). 2012 Feb;237(2):111-8. doi: 10.1258/ebm.2011.011208. Epub 2012 Jan 26.
Canonical transient receptor potential (TRPC) channel proteins have been identified as downstream molecules in a G protein-coupled receptor signaling pathway and are involved in a variety of cell functions due to their ability to regulate intracellular calcium signaling. TRPC channel physiology has been an increasingly interesting and relevant topic over the last decade, and the outcomes from various studies have advanced our understanding of TRPC function in the normal state. Recently, attention has turned to whether or not TRPC proteins are implicated in diseases. Emerging evidence suggests a significant contribution of several isoforms of TRPC proteins to cardiovascular as well as renal diseases. This review focuses on the implication of TRPC proteins as they pertain to diabetes. We summarize the recent findings by other investigators as well as ourselves and additionally discuss the important role of TRPC proteins in the development of various diabetic complications, such as diabetic nephropathy and diabetic vasculopathy. The underlying mechanisms which contribute to these complications are also outlined. Lastly, we elaborate on the role of TRPC proteins as a potential therapeutic target for treating diabetes-associated diseases.
经典瞬时受体电位 (TRPC) 通道蛋白已被确定为 G 蛋白偶联受体信号通路的下游分子，由于其能够调节细胞内钙信号，因此参与多种细胞功能。在过去的十年中，TRPC 通道生理学一直是一个越来越有趣和相关的话题，各种研究的结果提高了我们对 TRPC 在正常状态下功能的理解。最近，人们开始关注 TRPC 蛋白是否与疾病有关。新出现的证据表明，几种 TRPC 蛋白同工型对心血管疾病和肾脏疾病有重要贡献。本篇综述重点关注 TRPC 蛋白与糖尿病的关系。我们总结了其他研究人员以及我们自己的最新发现，并进一步讨论了 TRPC 蛋白在各种糖尿病并发症（如糖尿病肾病和糖尿病血管病变）发展中的重要作用。概述了导致这些并发症的潜在机制。最后，我们详细阐述了 TRPC 蛋白作为治疗与糖尿病相关疾病的潜在治疗靶点的作用。
