Trebak M, Lemonnier L, Smyth J T, Vazquez G, Putney J W
Laboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences-NIH, Research Triangle Park, PO Box 12233, NC 27709, USA.
Handb Exp Pharmacol. 2007(179):593-614. doi: 10.1007/978-3-540-34891-7_35.
The canonical transient receptor potential (TRPC) cation channels are mammalian homologs of the photoreceptor channel TRP in Drosophila melanogaster. All seven TRPCs (TRPC1 through TRPC7) can be activated through Gq/11 receptors or receptor tyrosine kinase (RTK) by mechanisms downstream of phospholipase C. The last decade saw a rapidly growing interest in understanding the role of TRPC channels in calcium entry pathways as well as in understanding the signal(s) responsible for TRPC activation. TRPC channels have been proposed to be activated by a variety of signals including store depletion, membrane lipids, and vesicular insertion into the plasma membrane. Here we discuss recent developments in the mode of activation as well as the pharmacological and electrophysiological properties of this important and ubiquitous family of cation channels.
典型瞬时受体电位（TRPC）阳离子通道是果蝇光感受器通道TRP在哺乳动物中的同源物。所有七种TRPC（TRPC1至TRPC7）都可以通过磷脂酶C下游的机制，经Gq/11受体或受体酪氨酸激酶（RTK）激活。在过去十年中，人们对了解TRPC通道在钙内流途径中的作用以及负责TRPC激活的信号的兴趣迅速增长。有人提出TRPC通道可被多种信号激活，包括内质网钙库耗竭、膜脂以及囊泡插入质膜。在此，我们讨论这个重要且普遍存在的阳离子通道家族在激活方式以及药理学和电生理学特性方面的最新进展。
