对张等人（2005年）的回应：在单相重度抑郁症中鉴定出的色氨酸羟化酶-2功能丧失突变。《神经元》第45卷，第11 - 16页。 - Suppr

Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.

作者信息

Zhou Zhifeng, Peters Eric J, Hamilton Steven P, McMahon Francis, Thomas Christee, McGrath Patrick J, Rush John, Trivedi Madhukar H, Charney Dennis S, Roy Alec, Wisniewski Stephen, Lipsky Robert, Goldman David

出版信息

Neuron. 2005 Dec 8;48(5):702-3; author reply 705-6. doi: 10.1016/j.neuron.2005.11.018.

DOI:10.1016/j.neuron.2005.11.018

PMID:16337901

Abstract

摘要

相似文献

Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.对张等人（2005年）的回应：在单相重度抑郁症中鉴定出的色氨酸羟化酶-2功能丧失突变。《神经元》第45卷，第11 - 16页。

Neuron. 2005 Dec 8;48(5):702-3; author reply 705-6. doi: 10.1016/j.neuron.2005.11.018.

Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.对张等人（2005年）的回应：在单相重度抑郁症中发现的色氨酸羟化酶-2功能丧失突变。《神经元》45卷，第11 - 16页。

Neuron. 2005 Dec 8;48(5):704-5; author reply 705-6. doi: 10.1016/j.neuron.2005.11.019.

Response to Zhang et al (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major Depression. Neuron 45, 11-16.对张等人（2005年）的回应：在单相重度抑郁症中鉴定出的色氨酸羟化酶-2功能丧失突变。《神经元》45卷，第11 - 16页。

Neuron. 2005 Dec 8;48(5):704; author reply 705-6. doi: 10.1016/j.neuron.2005.11.017.

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.在单相重度抑郁症中发现色氨酸羟化酶-2功能丧失突变。

Neuron. 2005 Jan 6;45(1):11-6. doi: 10.1016/j.neuron.2004.12.014.

The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder: results of meta-analyses.色氨酸羟化酶基因影响双相情感障碍的发病风险，但不影响重度抑郁症的发病风险：荟萃分析结果

Bipolar Disord. 2008 Nov;10(7):816-21. doi: 10.1111/j.1399-5618.2008.00623.x.

Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.抑郁症中的色氨酸羟化酶基因（TPH1）与外周血色氨酸水平

J Affect Disord. 2008 Jul;109(1-2):209-12. doi: 10.1016/j.jad.2007.11.010. Epub 2008 Feb 21.

Overview: a rare opportunity or just one less reason to be depressed.概述：这是一个难得的机会，还是只是又一个不必沮丧的理由。

Neuron. 2005 Dec 8;48(5):701-2; author reply 705-6. doi: 10.1016/j.neuron.2005.11.029.

TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.色氨酸羟化酶2基因多态性可能会改变难治性抑郁症的临床表现。

Neurosci Lett. 2009 Oct 16;464(1):43-6. doi: 10.1016/j.neulet.2009.08.018. Epub 2009 Aug 11.

Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder.色氨酸羟化酶1基因A218C多态性对重度抑郁症患者杏仁核在应对情感性面部刺激时活动的影响。

Genes Brain Behav. 2009 Jul;8(5):512-8. doi: 10.1111/j.1601-183X.2009.00500.x. Epub 2009 Jun 4.

A loss-of-function mutation in tryptophan hydroxylase 2 segregating with attention-deficit/hyperactivity disorder.色氨酸羟化酶2功能缺失突变与注意力缺陷多动障碍共分离。

Mol Psychiatry. 2008 Apr;13(4):365-7. doi: 10.1038/sj.mp.4002152.

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PLoS One. 2012;7(5):e36721. doi: 10.1371/journal.pone.0036721. Epub 2012 May 31.

Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.白细胞介素1A（IL1A）、白细胞介素1B（IL1B）、肿瘤坏死因子（TNF）、5-羟色胺受体2A（HTR2A）、5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）及色氨酸羟化酶2（TPH2）变异之间的上位效应并不影响酒精依赖障碍的特征。

Int J Environ Res Public Health. 2009 Jul;6(7):1980-90. doi: 10.3390/ijerph6071980. Epub 2009 Jul 16.

Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides.抑郁自杀者背侧和中缝核中神经元水平的色氨酸羟化酶-2 mRNA表达升高。

Mol Psychiatry. 2008 May;13(5):507-13, 465. doi: 10.1038/sj.mp.4002143. Epub 2008 Jan 8.

Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro.人类TPH2 5'调控区的功能特性：非翻译区和多态性在体外调节基因表达

Hum Genet. 2008 Jan;122(6):645-57. doi: 10.1007/s00439-007-0443-y. Epub 2007 Oct 31.

Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice.糖皮质激素对C57/Bl6小鼠中缝核中色氨酸羟化酶-2蛋白及前额叶皮质中5-羟色氨酸浓度的调节作用

Mol Psychiatry. 2008 May;13(5):498-506. doi: 10.1038/sj.mp.4002041. Epub 2007 Jul 10.

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Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.

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