Mattace-Raso Francesco U S, van der Cammen Tischa J M, van den Elzen Annette P M, Schalekamp Maarten A D H, Asmar Roland, Reneman Robert S, Hoeks Arnold P G, Hofman Albert, Witteman Jacqueline C M
Department of Epidemiology & Biostatistics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1479-83. doi: 10.1093/gerona/60.11.1479.
Light-to-moderate alcohol consumption has been associated with a lower risk of cardiovascular disease. The protective effect of alcohol could involve arterial properties as arterial stiffness and distensibility.
The relationship between alcohol and arterial stiffness was studied within the framework of the Rotterdam Study, a population-based study in individuals aged 55 and older. The present study included 3178 participants in the third examination phase. Arterial stiffness was measured by two different methods, i.e., the carotid-femoral pulse wave velocity and the DC of the common carotid artery. Categories of alcohol consumption were defined as follows: < or =3 glasses of alcohol per week, 4-10 glasses per week, 11-20 glasses per week, and > or =21 glasses per week. Linear regression analysis was used to investigate the association between alcohol consumption and measures of arterial stiffness.
In multivariate-adjusted models, women drinking 4-10, 11-20, and > or =21 glasses of alcoholic beverage per week had a -0.07 (0.22 to -0.38), -0.18 (0.12 to -0.49), and 0.12 (0.19 to -0.43) m/s difference in mean pulse wave velocity compared to those drinking 0-3 glasses per week (reference group). Corresponding differences in the carotid DC were 0.68 (1.21 to 0.15), 0.28 (0.82 to -0.25), and 0.36 (0.91 to -0.18) 10(-3)/kPa. In men, the estimates were not statistically significant, although a similar trend was observed.
Moderate alcohol consumption is associated with lower arterial stiffness in women independently of cardiovascular risk factors and atherosclerosis.
轻度至中度饮酒与较低的心血管疾病风险相关。酒精的保护作用可能涉及动脉特性，如动脉僵硬度和扩张性。
在鹿特丹研究的框架内研究了酒精与动脉僵硬度之间的关系，该研究是一项针对55岁及以上人群的基于人群的研究。本研究包括第三检查阶段的3178名参与者。通过两种不同的方法测量动脉僵硬度，即颈股脉搏波速度和颈总动脉的DC。饮酒类别定义如下：每周≤3杯酒、每周4 - 10杯、每周11 - 20杯以及每周≥21杯。使用线性回归分析来研究饮酒与动脉僵硬度测量值之间的关联。
在多变量调整模型中，与每周饮用0 - 3杯酒的女性（参照组）相比，每周饮用4 - 10杯、11 - 20杯以及≥21杯酒精饮料的女性，其平均脉搏波速度分别有-0.07（0.22至-0.38）、-0.18（0.12至-0.49）和0.12（0.19至-0.43）m/s的差异。颈总动脉DC的相应差异分别为0.68（1.21至0.15）、0.
