Dolinski Kara, Botstein David
Lewis-Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 USA.
Genome Res. 2005 Dec;15(12):1611-9. doi: 10.1101/gr.3727505.
Research with budding yeast (Saccharomyces cerevisiae) has been transformed by the publication, nearly a decade ago, of the entire genome DNA sequence. The introduction of this first eukaryotic genomic sequence changed the yeast research environment significantly, not just because of dramatic progress in technical means but also because the sequence made accessible a new class of scientific questions. A central goal of yeast research remains the determination of the biological role of every sequence feature in the yeast genome. The most remarkable change has been the shift in perspective from focus on individual genes and functionalities to a more global view of how the cellular networks and systems interact and function together to produce the highly evolved organism we see today.
近十年前，酿酒酵母（Saccharomyces cerevisiae）全基因组DNA序列的公布改变了相关研究。首个真核生物基因组序列的引入极大地改变了酵母研究环境，这不仅是因为技术手段取得了巨大进步，还因为该序列开启了一类新的科学问题。酵母研究的一个核心目标仍是确定酵母基因组中每个序列特征的生物学作用。最显著的变化是研究视角从关注单个基因和功能，转向更全面地看待细胞网络和系统如何相互作用并共同发挥功能，从而形成我们如今所见的高度进化的生物体。
