Department of Molecular Biology, Institute of Medical Microbiology and Centre for Molecular Biology and Neuroscience, Oslo University Hospital, Sognsvannsveien 20, NO-0027 Oslo, Norway.
Molecules. 2012 Aug 2;17(8):9258-73. doi: 10.3390/molecules17089258.
The budding yeast Saccharomyces cerevisiae is a widely used model organism, and yeast genetic methods are powerful tools for discovery of novel functions of genes. Recent advancements in chemical-genetics and chemical-genomics have opened new avenues for development of clinically relevant drug treatments. Systematic mapping of genetic networks by high-throughput chemical-genetic screens have given extensive insight in connections between genetic pathways. Here, I review some of the recent developments in chemical-genetic techniques in budding yeast.
出芽酵母酿酒酵母是一种广泛使用的模式生物，酵母遗传学方法是发现新基因功能的有力工具。化学遗传学和化学基因组学的最新进展为开发临床相关药物治疗方法开辟了新途径。通过高通量化学遗传学筛选对遗传网络进行系统映射，深入了解了遗传途径之间的联系。在这里，我回顾了酿酒酵母中化学遗传学技术的一些最新进展。
