Eschenhagen Thomas, Zimmermann Wolfram H
Institute of Experimental and Clinical Pharmacology, University Medical Center, Hamburg-Eppendorf, Germany.
Circ Res. 2005 Dec 9;97(12):1220-31. doi: 10.1161/01.RES.0000196562.73231.7d.
To create an artificial heart is one of the most ambitious dreams of the young field of tissue engineering, a dream that, when publicly announced in 1999 (LIFE initiative around M. Sefton), provoked as much compassion as scepticism in the scientific and lay press. Today, it is fair to state that the field is still far away from having built the "bioartificial heart." Nevertheless, substantial progress has been made over the past 10 years, and a realistic perspective exists to create 3-dimensional heart muscle equivalents that may not only serve as experimental models but could also be useful for cardiac regeneration.
制造一颗人造心脏是组织工程这一新兴领域最宏伟的梦想之一。1999年（围绕M. 塞夫顿的生命计划）这一梦想公开宣布时，在科学界和大众媒体中引发了同样多的同情与质疑。如今，可以说该领域距离制造出“生物人工心脏”仍有很大差距。然而，在过去十年中已经取得了实质性进展，并且存在一种现实的前景，即制造出三维心脏肌肉等效物，其不仅可以用作实验模型，还可能对心脏再生有用。
