Orrell Catherine
Desmond Tutu HIV Centre, IIDMM, Werner Beit Building-North, Medical School, Anzio Road, Observatory, Cape Town 7925, South Africa.
Curr HIV/AIDS Rep. 2005 Nov;2(4):171-6. doi: 10.1007/s11904-005-0012-8.
Adherence is key to successful antiretroviral therapy (ART). Many countries with increased HIV prevalence and the greatest need for ART have limited health resources. Recent assumptions that the adherence required for successful ART will not be achieved in resource-poor settings have led to calls for caution in expanded access programs. New studies from Africa refute this, showing excellent adherence and virologic outcomes. Major factors contributing to adherence or nonadherence are whether the drug is accessed for free or is self-funded, patient preparedness for use of ART, stigmatization related to being HIV-positive, and ease of use of regimen.
坚持服药是抗逆转录病毒疗法（ART）成功的关键。许多艾滋病毒感染率上升且最需要抗逆转录病毒疗法的国家，卫生资源有限。最近有人认为，在资源匮乏地区无法实现成功的抗逆转录病毒疗法所需的坚持服药，这导致人们呼吁在扩大治疗项目时要谨慎。非洲的新研究反驳了这一观点，显示出很高的坚持服药率和病毒学治疗效果。导致坚持服药或不坚持服药的主要因素包括药物是免费获得还是自费、患者对使用抗逆转录病毒疗法的准备情况、与艾滋病毒呈阳性相关的污名化以及治疗方案的易用性。
