丙戊酸治疗的癫痫患者体内的瘦素、胃饥饿素和脂联素
Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid.
作者信息
Greco R, Latini G, Chiarelli F, Iannetti P, Verrotti A
机构信息
Department of Medicine, University of Chieti, Italy.
出版信息
Neurology. 2005 Dec 13;65(11):1808-9. doi: 10.1212/01.wnl.0000187074.27586.d1.
Abstract
The authors studied 40 epileptic patients treated with valproate and 40 healthy controls for at least 2 years. At the end of follow-up, 15 epileptic patients (37.5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight.
摘要
作者对40名接受丙戊酸盐治疗的癫痫患者和40名健康对照者进行了至少2年的研究。随访结束时，15名癫痫患者（37.5%）出现了肥胖。他们的循环瘦素和胰岛素水平显著高于未增重患者，而胃饥饿素和脂联素水平则显著低于未增重患者。
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