类固醇对多烯类抗生素抗真菌活性的干扰。
Steroid interference with antifungal activity of polyene antibiotics.
作者信息
Zygmunt W A, Tavormina P A
机构信息
Department of Microbiology and Natural Products Research, Mead Johnson & Company, Evansville, Indiana.
出版信息
Appl Microbiol. 1966 Nov;14(6):865-9. doi: 10.1128/am.14.6.865-869.1966.
Abstract
Wide differences exist among the polyene antibiotics, nystatin, rimocidin, filipin, pimaricin, and amphotericin B, with reference to steroid interference with their antifungal activities against Candida albicans. Of the numerous steroids tested, ergosterol was the only one which effectively antagonized the antifungal activity of all five polyene antibiotics. The antifungal activities of nystatin and amphotericin B were the least subject to vitiation by the addition of steroids other than ergosterol, and those of filipin, rimocidin, and pimaricin were the most sensitive to interference. Attempts to delineate the structural requirements of steroids possessing polyene-neutralizing activity in growing cultures of C. albicans are discussed. The ultraviolet absorbance of certain antibiotic steroid combinations was also studied.
摘要
多烯抗生素（制霉菌素、龟裂杀菌素、菲律宾菌素、匹马菌素和两性霉素B）在甾体干扰其对白色念珠菌的抗真菌活性方面存在很大差异。在测试的众多甾体中，麦角固醇是唯一能有效拮抗所有五种多烯抗生素抗真菌活性的甾体。除麦角固醇外，添加其他甾体时，制霉菌素和两性霉素B的抗真菌活性受影响最小，而菲律宾菌素、龟裂杀菌素和匹马菌素的抗真菌活性对干扰最为敏感。本文讨论了在白色念珠菌生长培养物中描绘具有多烯中和活性的甾体结构要求的尝试。还研究了某些抗生素 - 甾体组合的紫外吸光度。
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Alterations in the permeability of Neurospora crassa due to polyene antibiotics.多烯抗生素对粗糙脉孢菌通透性的影响。
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Location and role of sterol at nystatin-binding sites.制霉菌素结合位点处固醇的位置与作用
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Effect of high concentrations of nystatin upon glycolysis and cellular permeability in yeast.高浓度制霉菌素对酵母糖酵解及细胞通透性的影响
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Leishmanicidal activity of nystatin, a polyene antifungal antibiotic. I. The probable mechanism of action of nystatin on Leishmania donovani.制霉菌素（一种多烯类抗真菌抗生素）对利什曼原虫的杀伤活性。I. 制霉菌素对杜氏利什曼原虫的可能作用机制。
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The effect of monovalent cations on the inhibition of yeast metabolism by nystatin.单价阳离子对制霉菌素抑制酵母代谢的影响。
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