吖啶橙对新城疫病毒的光动力灭活作用

Photodynamic inactivation of newcastle disease virus with acridine orange.

作者信息

Frank G H, Foster J W

机构信息

Department of Microbiology and Preventive Medicine, School of Veterinary Medicine, University of Georgia Athens, Georgia 30602.

出版信息

Appl Microbiol. 1967 Nov;15(6):1452-5. doi: 10.1128/am.15.6.1452-1455.1967.

DOI:10.1128/am.15.6.1452-1455.1967

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC547231/

Abstract

Newcastle disease virus in allantoamnionic fluid was photosensitized with acridine orange, and then photodynamically inactivated. The inactivation rate was directly proportional to light intensity and to dye concentrations up to a level of approximately 100 to 200 mug/ml. Inactivation occurred at approximately an exponential rate for the first 4.5 log(10) units of virus, and then continued at a decreasing rate.

摘要

将尿囊羊水中的新城疫病毒用吖啶橙进行光敏化处理，然后进行光动力灭活。灭活率与光强度以及染料浓度直接成正比，直至染料浓度达到约100至200微克/毫升的水平。在病毒最初的4.5个对数（10）单位中，灭活以近似指数速率发生，然后以递减速率继续。

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本文引用的文献

1

Inactivation of viruses by the photodynamic action of toluidine blue.通过甲苯胺蓝的光动力作用使病毒失活。

J Immunol. 1960 May;84:480-4.

2

KINETICS OF THE INACTIVATION OF VIRUSES.病毒灭活动力学

Bacteriol Rev. 1964 Jun;28(2):150-63. doi: 10.1128/br.28.2.150-163.1964.

3

Cytochemical and fluorescent antibody studies on the growth of poliovirus in tissue culture.关于脊髓灰质炎病毒在组织培养中生长的细胞化学和荧光抗体研究。

Tex Rep Biol Med. 1961;19:106-22.

4

Photodynamic inactivation of infectious nucleic acid.感染性核酸的光动力失活

Science. 1960 Dec 16;132(3442):1840-1. doi: 10.1126/science.132.3442.1840.

5

Vital staining of blood parasites with acridine orange.用吖啶橙对血液寄生虫进行活体染色。

J Parasitol. 1958 Dec;44(6):588-94.

6

Fluorescence microscopy in the study of nucleic acids; histochemical observations on cellular and virus nucleic acids.核酸研究中的荧光显微镜术；关于细胞和病毒核酸的组织化学观察。

Nature. 1957 Dec 14;180(4598):1335-6. doi: 10.1038/1801335a0.

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