γ射线辐射使委内瑞拉马脑炎病毒失活
Inactivation of Venezuelan Equine Encephalomyelitis Virus by gamma-Radiation.
作者信息
Reitman M, Tribble H R
机构信息
Medical Sciences Laboratory and Biological Sciences Laboratory, Fort Detrick, Frederick, Maryland 21701.
出版信息
Appl Microbiol. 1967 Nov;15(6):1456-9. doi: 10.1128/am.15.6.1456-1459.1967.
Abstract
Exposure of Venezuelan equine encephalomyelitis (VEE) virus (at -70 C) to 6 x 10 r gamma-radiation (Co) resulted in loss of lethality for young adult mice and guinea pigs, and loss of capacity to produce plaques or cytopathic effects in tissue culture. The suckling mouse was more sensitive for detecting live virus in radiated suspensions than was the adult mouse or guinea pig. Live virus was demonstrable in preparations exposed to 6 x 10 r but not in suspensions exposed to 8 x 10 r and more. The rate of inactivation of VEE virus by gamma-radiation was an exponential function of the dosage.
摘要
委内瑞拉马脑炎（VEE）病毒（在-70℃下）暴露于6×10拉德的γ辐射（钴）后，对年轻成年小鼠和豚鼠的致死性丧失，并且在组织培养中产生蚀斑或细胞病变效应的能力丧失。乳鼠比成年小鼠或豚鼠在检测经辐射的悬液中的活病毒方面更敏感。在暴露于6×10拉德的制剂中可证明有活病毒，但在暴露于8×10拉德及更高剂量的悬液中则没有。γ辐射使VEE病毒失活的速率是剂量的指数函数。
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