自组装分子钉板。

Self-assembling a molecular pegboard.

作者信息

Lund Kyle, Liu Yan, Lindsay Stuart, Yan Hao

机构信息

Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA.

出版信息

J Am Chem Soc. 2005 Dec 21;127(50):17606-7. doi: 10.1021/ja0568446.

DOI:10.1021/ja0568446

PMID:16351081

Abstract

This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.

摘要

本文描述了一种由纳米尺寸的DNA瓦片自组装而成的、具有化学可寻址性的DNA纳米网格的设计、构建及应用。这种自组装结构允许分子精确地定位在“分子钉板”上的预定位置。我们使用带索引的DNA纳米网格来识别在特定位置杂交的单个DNA分子。