小鼠巨细胞病毒编码的假定主要组织相容性复合体I类（MHC-I）样蛋白m157的表达独立于病毒对宿主MHC-I的调控。
Expression of m157, a murine cytomegalovirus-encoded putative major histocompatibility class I (MHC-I)-like protein, is independent of viral regulation of host MHC-I.
作者信息
Tripathy Sandeep K, Smith Hamish R C, Holroyd Erika A, Pingel Jeanette T, Yokoyama Wayne M
机构信息
Washington University School of Medicine, Gastroenterology Division, Department of Medicine, St. Louis, MO 63110, USA.
出版信息
J Virol. 2006 Jan;80(1):545-50. doi: 10.1128/JVI.80.1.545-550.2006.
Abstract
A murine cytomegalovirus (MCMV)-encoded protein, m157, has a putative major histocompatibility complex class I (MHC-I) structure and is recognized by the Ly49H NK cell activation receptor. Using a monoclonal antibody against m157, in this study we directly demonstrated that m157 is a cell surface-expressed glycophosphatidylinositol-anchored protein with early viral gene kinetics. Beta-2 microglobulin and TAP1 (transporter associated with antigen processing 1) were not required for its expression. MCMV-encoded proteins that down-regulate MHC-I did not affect the expression of m157. Thus, m157 is expressed on infected cells in a manner independent of viral regulation of host MHC-I.
摘要
一种小鼠巨细胞病毒（MCMV）编码的蛋白m157，具有推定的主要组织相容性复合体I类（MHC-I）结构，且可被Ly49H自然杀伤细胞激活受体识别。在本研究中，我们使用一种针对m157的单克隆抗体，直接证明m157是一种具有早期病毒基因动力学的细胞表面表达的糖基磷脂酰肌醇锚定蛋白。其表达不需要β2微球蛋白和TAP1（抗原加工相关转运体1）。下调MHC-I的MCMV编码蛋白不影响m157的表达。因此，m157以独立于病毒对宿主MHC-I调节的方式在受感染细胞上表达。
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Expression of m157, a murine cytomegalovirus-encoded putative major histocompatibility class I (MHC-I)-like protein, is independent of viral regulation of host MHC-I.小鼠巨细胞病毒编码的假定主要组织相容性复合体I类（MHC-I）样蛋白m157的表达独立于病毒对宿主MHC-I的调控。
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