Rudlowski Christian, Schulten Hans-Jürgen, Golas Mariola Monika, Sander Bjoern, Barwing Roland, Palandt Jens-Ekkehard, Schlehe Bettina, Lindenfelser Rüdiger, Moll Roland, Liersch Torsten, Schumpelick Volker, Gunawan Bastian, Füzesi László
Department of Obstetrics and Gynecology, University of Bonn, Germany.
Int J Cancer. 2006 May 15;118(10):2455-60. doi: 10.1002/ijc.21646.
The spectrum of genetic alterations in primary male breast cancer is not well established. We analyzed chromosomal imbalances in 39 tumor samples from primary male breast cancer by comparative genomic hybridization (CGH) and correlated CGH findings with clinicopathological factors. Chromosomal gains were most frequent at 1q (46%), 8q (46%), 16p (36%), 17q (36%), Xq (28%), 20q (26%) and Xp (18%). Losses were most commonly observed at 8p (36%), 16q (28%), 13q (28%), 6q (18%), 11q (18%) and 22q (18%). Gains at 16p, 20q and Xq and losses at 13q correlated significantly with higher degree of cytogenetic complexity. Significant associations with clinicopathological factors were observed for +8q and -16q with larger tumor size and -16q with lower proliferative activity and lower grade of malignancy. A comparison with reported CGH data from female breast cancer showed a similar pattern of chromosomal imbalances, including +1q, -8p, +8q, -13q, +16p, -16q, +17q and +20q. Our results indicate that male breast cancer shares a common pattern of imbalances with female breast cancer, suggesting that similar genetic events may underlie the development and progression of male and female breast cancer.
原发性男性乳腺癌的基因改变谱尚未完全明确。我们通过比较基因组杂交（CGH）分析了39例原发性男性乳腺癌肿瘤样本中的染色体失衡情况，并将CGH结果与临床病理因素进行关联分析。染色体增加最常见于1q（46%）、8q（46%）、16p（36%）、17q（36%）、Xq（28%）、20q（26%）和Xp（18%）。缺失最常出现在8p（36%）、16q（28%）、13q（28%）、6q（18%）、11q（18%）和22q（18%）。16p、20q和Xq的增加以及13q的缺失与细胞遗传学复杂性程度较高显著相关。观察到+8q和-16q与较大肿瘤大小、-16q与较低增殖活性和较低恶性程度与临床病理因素存在显著关联。与报道的女性乳腺癌CGH数据比较显示，染色体失衡模式相似，包括+1q、-8p、+8q、-13q、+16p、-16q、+17q和+20q。我们的结果表明，男性乳腺癌与女性乳腺癌存在共同的失衡模式，提示相似的基因事件可能是男性和女性乳腺癌发生发展的基础。
