Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education and Key Laboratory of Cancer Prevention and Therapy, Tianjin, Medical University Cancer Institute and Hospital, He Xi District, Tianjin, 300060 China.
Hum Pathol. 2011 Nov;42(11):1693-701. doi: 10.1016/j.humpath.2010.12.027. Epub 2011 Apr 29.
Centrosome abnormalities occur frequently in various tumors and can cause chromosomal instability and eventually promote cancer development. We investigated the chromosome aberrations associated with centrosome abnormalities in 30 cases of breast cancer, combining immunohistochemical staining and comparative genomic hybridization. Except for some common chromosome alterations (including gains of 1q, 8q, 17q, 20q, and Xq and losses of 8p, 11q, 13q, 14q, 16q, 17p, 22q, and Xp) that have also been seen more frequently in other studies, we discovered some new changes that have rarely been reported, including gains at 2p, 5p, 10p, 15q, 16p, 18q, 21q, and 22q and losses at 6p, 8p23, 11p13-pter, 13q34, and 14q32-qter. We also identified some changes (such as gains of 17q, 20q, and Xq and losses of 17p, 13q, and 14q) harboring candidate genes. We also explored the expression of centrosome protein in different molecular subtypes of breast cancer. Our findings provide a new way to explore the molecular mechanisms of breast tumorigenesis and accordingly potential new targets for therapy for this disease.
中心体异常在各种肿瘤中经常发生，可导致染色体不稳定，最终促进癌症的发展。我们结合免疫组织化学染色和比较基因组杂交技术，研究了 30 例乳腺癌中与中心体异常相关的染色体畸变。除了一些在其他研究中也更频繁出现的常见染色体改变（包括 1q、8q、17q、20q 和 Xq 的增益和 8p、11q、13q、14q、16q、17p、22q 和 Xp 的缺失）外，我们还发现了一些很少有报道的新变化，包括 2p、5p、10p、15q、16p、18q、21q 和 22q 的增益以及 6p、8p23、11p13-pter、13q34 和 14q32-qter 的缺失。我们还鉴定了一些包含候选基因的变化（如 17q、20q 和 Xq 的增益以及 17p、13q 和 14q 的缺失）。我们还探索了不同分子亚型乳腺癌中中心体蛋白的表达。我们的研究结果为探索乳腺癌发生的分子机制提供了一种新的方法，并为这种疾病的治疗提供了潜在的新靶点。
