Shiraishi H, Koizumi J, Hori M, Terashima Y, Suzuki T, Saito K, Mizukami K, Tanaka Y, Yamaguchi N
Department of Psychiatry, University of Tsukuba, Ibaraki.
Jpn J Psychiatry Neurol. 1992 Mar;46(1):99-105. doi: 10.1111/j.1440-1819.1992.tb00823.x.
This is a description of a computerized tomographic study of 45 non-delusional depressed, 29 delusional depressed patients and 77 neurotic control subjects. The cerebral atrophy ratio (CAR) on the three different slices and the ventricular ratio (VBR) of the anterior horn and the body of the lateral ventricles were calculated, analyzed and compared using Student's t test. Compared to the control subjects, the non-delusional depressive patients had greater CAR values than the controls but there were no significant differences of VBR values between the two groups. The patients with delusional depression had significantly larger CAR and VBR values than the non-delusional depressives and control subjects. The delusional depressives had greater brain atrophy than the non-delusionals and it was suggested that organic cerebral factors may have etiological significance in the depressions, especially the delusional depressives.
这是一项针对45名非妄想性抑郁症患者、29名妄想性抑郁症患者和77名神经症对照受试者的计算机断层扫描研究描述。计算、分析并使用学生t检验比较了三个不同切片上的脑萎缩率（CAR）以及侧脑室前角和体部的脑室率（VBR）。与对照受试者相比，非妄想性抑郁症患者的CAR值高于对照组，但两组之间的VBR值无显著差异。妄想性抑郁症患者的CAR和VBR值显著大于非妄想性抑郁症患者和对照受试者。妄想性抑郁症患者的脑萎缩比非妄想性抑郁症患者更严重，提示器质性脑因素可能在抑郁症尤其是妄想性抑郁症的病因学中具有重要意义。
