Van den Bossche B, Maes M, Brussaard C, Schotte C, Cosyns P, De Moor J, De Schepper A
Department of Psychiatry, University Hospital Antwerp, Edegem, Belgium.
J Affect Disord. 1991 Jan;21(1):67-74. doi: 10.1016/0165-0327(91)90020-s.
Several authors have reported enlarged lateral brain ventricles in major depressive patients as compared to healthy controls. Also, the enlargement of brain lateral ventricles has been related to delusions, psychomotor retardation and some biochemical data such as cortisol secretion and L-tryptophan serum levels. The present study was undertaken to investigate if melancholic depressives are characterised by a higher degree of brain atrophy than normal controls and minor depressives, the origin of any brain atrophy, and whether measures of brain atrophy are related to cortisol secretion and L-tryptophan serum levels. We investigated 10 healthy controls and 35 depressive patients categorised according to DSM-III. In contrast to previous studies, we determined a combination of indices which makes it possible to differentiate between central and cortical diffuse atrophy. We found no evidence for the existence of abnormal atrophy of the brain in melancholics; nor did we find any correlation between CT scan measurements and cortisol or tryptophan.
几位作者报告称，与健康对照组相比，重度抑郁症患者的侧脑室增大。此外，脑侧脑室增大与妄想、精神运动迟缓以及一些生化数据有关，如皮质醇分泌和血清L-色氨酸水平。本研究旨在调查抑郁性抑郁症患者是否比正常对照组和轻度抑郁症患者具有更高程度的脑萎缩，任何脑萎缩的起源，以及脑萎缩指标是否与皮质醇分泌和血清L-色氨酸水平相关。我们调查了10名健康对照者和35名根据《精神疾病诊断与统计手册》第三版（DSM-III）分类的抑郁症患者。与先前的研究不同，我们确定了一组指标组合，使得区分中枢性和皮质弥漫性萎缩成为可能。我们没有发现抑郁性抑郁症患者存在异常脑萎缩的证据；我们也没有发现CT扫描测量结果与皮质醇或色氨酸之间存在任何相关性。
