Ward B G, Joy G J, Ramm L E, Baker C A, McGuckin M A
University of Queensland Department of Obstetrics and Gynaecology, Royal Brisbane Hospital, Herston.
Med J Aust. 1992 Aug 3;157(3):161-4. doi: 10.5694/j.1326-5377.1992.tb137077.x.
To compare mammary serum antigen (MSA) levels with mammography as a screening test for breast cancer. To determine the value of MSA testing to decrease the need for women to undergo mammography.
A blind prospective comparison of MSA levels and mammography to detect breast cancer.
Royal Women's Hospital Breast Cancer Screening Clinic. Women were mainly self-referred.
MSA levels had a wide range in normal women and women with mammography-detected breast cancer. Mean MSA levels in women with breast cancer reflected tumour volume, but a wide range was again seen. At 60% specificity, the sensitivity of an elevated MSA level for breast cancer was 63% for invasive cancer and zero for in-situ disease. MSA levels were modestly but significantly elevated in smokers over non-smokers.
The MSA level is an insufficiently sensitive or specific marker to have a role in screening for breast cancer.
比较乳腺血清抗原（MSA）水平与乳房X线摄影作为乳腺癌筛查试验的效果。确定MSA检测对于减少女性接受乳房X线摄影需求的价值。
对MSA水平与乳房X线摄影进行盲法前瞻性比较以检测乳腺癌。
皇家妇女医院乳腺癌筛查诊所。女性主要为自我转诊。
正常女性和乳房X线摄影检测出乳腺癌的女性中，MSA水平范围广泛。乳腺癌女性的平均MSA水平反映了肿瘤体积，但同样存在广泛范围。在特异性为60%时，MSA水平升高对乳腺癌的敏感性，浸润性癌为63%，原位癌为零。吸烟者的MSA水平比非吸烟者略有但显著升高。
MSA水平作为乳腺癌筛查的标志物，其敏感性或特异性不足，无法发挥作用。
