Sartor Belinda M, Dickey Richard P
Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, Fertility Institute of New Orleans, Louisiana 70001, USA.
Am J Med Sci. 2005 Dec;330(6):336-42. doi: 10.1097/00000441-200512000-00012.
Polycystic ovarian syndrome (PCOS), first described in 1937, was defined by specific ovarian histopathology and a constellation of signs and symptoms. Through the years, the etiology remained elusive, with heated debates focusing in turn on the ovary and then the pituitary as the causative agents. In the last several decades, it has become clear that insulin resistance makes up a very important component of this syndrome. With this knowledge, new therapies have emerged along with the realization that PCOS and the metabolic syndrome are closely related through their shared insulin resistance. In this review, the diagnosis, pathophysiology, and therapy of PCOS are discussed and upon this background, those areas held in common by PCOS and the metabolic syndrome are explored.
多囊卵巢综合征（PCOS）于1937年首次被描述，由特定的卵巢组织病理学以及一系列体征和症状所定义。多年来，其病因一直难以捉摸，激烈的争论先后聚焦于卵巢和垂体，认为它们是致病因素。在过去几十年里，很明显胰岛素抵抗是该综合征的一个非常重要的组成部分。基于这一认识，随着人们意识到PCOS与代谢综合征通过共同的胰岛素抵抗密切相关，新的治疗方法应运而生。在这篇综述中，我们讨论了PCOS的诊断、病理生理学和治疗方法，并在此背景下探讨了PCOS与代谢综合征的共同之处。
