Gariano Ray F, Gardner Thomas W
Department of Ophthalmology, A-157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA.
Nature. 2005 Dec 15;438(7070):960-6. doi: 10.1038/nature04482.
The retina has long been regarded as 'an approachable part of the brain' for investigating neurosensory processes. Cell biologists are now capitalizing on the accessibility of the retina to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases.
长期以来，视网膜一直被视为研究神经感觉过程的“大脑可及部分”。细胞生物学家现在正利用视网膜的易接近性来研究发育性血管生成的重要方面，包括其与神经元和神经胶质细胞发育、形态发生、氧感应及祖细胞的关系。病理性血管生成也发生在视网膜，并且是主要致盲疾病（尤其是糖尿病性视网膜病变）的一个主要特征。视网膜及其临床病症在血管生成研究中具有关键作用，并提供了用于研究神经血管关系和血管生成性疾病的模型系统。
