Kaur Savneet, Thiel Steffen, Sarma P Usha, Madan Taruna
Department of Molecular Biochemistry and Diagnostics, Institute of Genomics and Integrative Biology, Mall Road, Delhi-100 007, India.
Curr Allergy Asthma Rep. 2006 Sep;6(5):377-83. doi: 10.1007/s11882-996-0007-6.
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line host-defense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.
甘露聚糖结合凝集素(MBL)是固有免疫中一种重要且多功能的成分。它存在于血清中,可与多种微生物病原体结合,并通过补体依赖和/或非依赖机制介导这些病原体的调理作用。血清中MBL水平较低归因于某些基因多态性,是导致多种传染病的主要因素。然而,最近的研究表明,MBL的作用不仅局限于其作为一线宿主防御分子的经典角色,还扩展到了炎症调节方面。在本综述中,我们总结并探讨了MBL在哮喘和过敏中的这种潜在及可能的新作用。