Nauta Alma J, Roos Anja, Daha Mohamed R
Leiden University Medical Center, Nephrology Department, Leiden, The Netherlands.
Int Arch Allergy Immunol. 2004 Aug;134(4):310-23. doi: 10.1159/000079261. Epub 2004 Jun 23.
The complement system comprises a strong defense against various pathogens and is a major component of our innate immune system. While earlier studies have established a crucial role of complement in recognition, opsonization and enhanced phagocytosis of microorganisms by professional phagocytes such as polymorphonuclear leukocytes and macrophages, recent studies delineate an additional role of complement in initiation and maintenance of the acquired immune response. In addition, it seems that opsonization of apoptotic cells by complement may lead to polarization of the response of professional antigen-presenting cells to a more inflammatory or tolerogenic response. The present review summarizes these different contributions of complement to the shaping of the immune balance.
补体系统是抵御各种病原体的强大防线，也是我们先天免疫系统的主要组成部分。虽然早期研究已证实补体在多形核白细胞和巨噬细胞等专业吞噬细胞识别、调理和增强对微生物的吞噬作用中起关键作用，但最近的研究表明补体在获得性免疫反应的启动和维持中还有额外作用。此外，补体对凋亡细胞的调理作用似乎可能导致专业抗原呈递细胞的反应偏向更具炎症性或耐受性的反应。本综述总结了补体对免疫平衡形成的这些不同贡献。
