Van Handel Daniel, Fass Ronnie
The Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA.
J Gastroenterol Hepatol. 2005 Dec;20 Suppl:S6-13. doi: 10.1111/j.1440-1746.2005.04165.x.
Various underlying mechanisms have been described in patients with non-cardiac chest pain (NCCP). By far, gastroesophageal reflux disease (GERD) is the most common cause and thus requires initial attention when patients with NCCP are managed. Esophageal dysmotility can be demonstrated in 30% of the NCCP patients, but appears to play a very limited role in symptom generation. A significant number of patients with NCCP lack any evidence of GERD and have been consistently shown to have reduced perception thresholds for pain. Peripheral and/or central sensitization have been suggested to be responsible for visceral hypersensivity in NCCP patients. Further understanding of the underlying mechanisms for pain in patients with NCCP will likely improve our current therapeutic approach.
非心源性胸痛（NCCP）患者存在多种潜在机制。到目前为止，胃食管反流病（GERD）是最常见的病因，因此在处理NCCP患者时需要首先予以关注。30%的NCCP患者可表现出食管动力障碍，但在症状产生中似乎作用非常有限。相当一部分NCCP患者没有GERD的任何证据，且一直显示其疼痛感知阈值降低。外周和/或中枢敏化被认为是NCCP患者内脏超敏反应的原因。进一步了解NCCP患者疼痛的潜在机制可能会改善我们目前的治疗方法。
