Geisler Markus, Murphy Angus S
Zurich-Basel Plant Science Center, Institute of Plant Biology, University of Zurich, CH-8007 Zurich, Switzerland.
FEBS Lett. 2006 Feb 13;580(4):1094-102. doi: 10.1016/j.febslet.2005.11.054. Epub 2005 Dec 6.
A surprising outcome of the Arabidopsis genome project was the annotation of a large number of sequences encoding members of the ABC transporter superfamily, including 22 genes encoding the p-glycoprotein (PGP) subfamily. As mammalian PGP orthologs are associated with multiple drug resistance, plant PGPs were initially presumed to function in detoxification, but were soon seen to have a developmental role. Here, we summarise recent studies of plant PGPs indicating that PGPs mediate the cellular and long-distance transport of the plant hormone auxin. One class of PGPs, represented by AtPGP1, catalyze auxin export, while another class with at least one member, AtPGP4, appears to function in auxin import. Current models on the physiological role of PGPs, their functional interaction and their involvement in cell-to cell (polar) auxin transport are discussed.
拟南芥基因组计划的一个惊人成果是对大量编码ABC转运蛋白超家族成员的序列进行了注释，其中包括22个编码P-糖蛋白（PGP）亚家族的基因。由于哺乳动物PGP直系同源物与多药耐药性相关，植物PGP最初被认为在解毒中起作用，但很快就发现它们具有发育作用。在这里，我们总结了最近对植物PGP的研究，表明PGP介导植物激素生长素的细胞内和长距离运输。一类以AtPGP1为代表的PGP催化生长素输出，而另一类至少有一个成员AtPGP4似乎在生长素输入中起作用。本文还讨论了关于PGP生理作用、其功能相互作用以及它们参与细胞间（极性）生长素运输的当前模型。
