Yesilkaya Hasan, Forbes Ken J, Shafi Jamila, Smith Rebecca, Dale Jeremy W, Rajakumar Kumar, Barer Michael R, Andrew Peter W
Department of Infection, Immunity and Inflammation, Leicester Medical School, University of Leicester, Leicester LE1 9HN, UK.
Tuberculosis (Edinb). 2006 Sep;86(5):357-62. doi: 10.1016/j.tube.2005.08.019. Epub 2005 Dec 19.
Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed.
结核分枝杆菌基因组中的独特事件，包括缺失和IS6110插入，被认为是导致暴发菌株毒力表型的原因。基于这一前提，我们确定了结核分枝杆菌CH菌株基因组中的10个IS6110插入位点，该菌株曾在英国莱斯特郡引发大规模疫情。结合先前关于基因组缺失的数据，发现有16个基因因IS6110插入或缺失而发生突变。本文讨论了这些基因组事件对CH菌株表型可能产生的影响。
