甲状腺淋巴瘤：单机构经验
Thyroid lymphoma: a single institution's experience.
作者信息
Ruggiero Francis P, Frauenhoffer Elizabeth, Stack Brendan C
机构信息
Division of Otolaryngology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
出版信息
Otolaryngol Head Neck Surg. 2005 Dec;133(6):888-96. doi: 10.1016/j.otohns.2005.07.040.
BACKGROUND
Primary lymphoma of the thyroid gland is uncommon.
METHODS
The tumor registry at the Penn State Milton S. Hershey Medical Center was searched for all patients carrying a diagnosis of thyroid lymphoma. All available records for these patients were examined and information regarding patient and tumor characteristics, clinical presentation, interventions, and survival were tabulated.
RESULTS
The average age of patient in our series was 67.5 years. There was a 2.7:1 female to male preponderance. Thirteen (60%) patients presented with thyroid nodule(s). Eleven (50%) presented with aerodigestive tract obstructive symptoms. Sixteen (73%) patients had no pre-existing history of thyroid disease; none had known pre-existing Hashimoto's thyroiditis.
CONCLUSIONS
The typical thyroid lymphoma patient is female and elderly with painless thyroid enlargement. Compressive symptoms of the aerodigestive tract are common at presentation and may require urgent intervention. Treatment modalities (XRT, CHOP chemotherapy) and outcomes are distinct from other thyroid malignancies.
背景
原发性甲状腺淋巴瘤并不常见。
方法
检索宾夕法尼亚州立大学米尔顿·S·赫尔希医疗中心的肿瘤登记处，查找所有诊断为甲状腺淋巴瘤的患者。检查这些患者的所有可用记录，并将有关患者和肿瘤特征、临床表现、干预措施及生存情况的信息制成表格。
结果
我们研究系列中的患者平均年龄为67.5岁。女性与男性的比例为2.7:1，女性占优势。13例（60%）患者表现为甲状腺结节。11例（50%）表现为气消化道梗阻症状。16例（73%）患者既往无甲状腺疾病史；均无已知的桥本甲状腺炎病史。
结论
典型的甲状腺淋巴瘤患者为老年女性，甲状腺无痛性肿大。气消化道压迫症状在就诊时很常见，可能需要紧急干预。治疗方式（放疗、CHOP化疗）及治疗结果与其他甲状腺恶性肿瘤不同。
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