Sakamoto K, Arakawa H, Yamashita S, Mizuta H, Takaki K, Ogawa M
Department of Surgery II, Kumamoto University Medical School, Japan.
Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):279-85.
To investigate the clinical significance of membrane-associated phospholipase A2 (M-PLA2) measured by a radioimmunoassay(RIA) in rheumatoid arthritis, we examined serum M-PLA2 concentrations in 16 patients with rheumatoid arthritis. All showed elevated levels of serum M-PLA2. On the other hand, serum concentrations of C-reactive protein (CRP) and IL-6 were increased in 13 (81.3%) and 14 (87.5%) of 16 patients, respectively. The serum concentrations of M-PLA2 were significantly correlated with those of CRP. These results indicate that M-PLA2 is an acute phase reactant and a sensitive and useful marker of inflammation in rheumatoid arthritis.
为了研究通过放射免疫分析法（RIA）测定的膜相关磷脂酶A2（M-PLA2）在类风湿性关节炎中的临床意义，我们检测了16例类风湿性关节炎患者的血清M-PLA2浓度。所有患者的血清M-PLA2水平均升高。另一方面，16例患者中分别有13例（81.3%）和14例（87.5%）的C反应蛋白（CRP）和IL-6血清浓度升高。M-PLA2的血清浓度与CRP的血清浓度显著相关。这些结果表明，M-PLA2是一种急性期反应物，是类风湿性关节炎炎症的敏感且有用的标志物。
