Ogawa M, Arakawa H, Yamashita S, Sakamoto K, Ikei S
Department of Surgery II, Kumamoto University Medical School, Japan.
Res Commun Chem Pathol Pharmacol. 1992 Jan;75(1):109-15.
Elevations of serum immunoreactive interleukin 6 (IL-6) and Group II phospholipase A2 (M-PLA2) were observed without exception after elective surgeries for various sites. Serum IL-6 rose steeply after surgery, and reached the maximum level on the 1st postoperative day. Serum M-PLA2 increased from the 1st postoperative day and reached the maximum level on the 2nd postoperative day in 10 patients (76.9%), on the first day after surgery in 2 patients and on the 3rd day in one patient. The peak serum M-PLA2 after surgery was significantly correlated with the peak IL-6 and blood loss volume during surgery. These results suggested that serum M-PLA2 is an acute phase reactant.
在对不同部位进行择期手术后，无一例外均观察到血清免疫反应性白细胞介素6（IL-6）和II组磷脂酶A2（M-PLA2）升高。血清IL-6在术后急剧上升，并在术后第1天达到最高水平。血清M-PLA2在术后第1天开始升高，10例患者（76.9%）在术后第2天达到最高水平，2例患者在术后第1天达到最高水平，1例患者在术后第3天达到最高水平。术后血清M-PLA2峰值与峰值IL-6及术中失血量显著相关。这些结果提示血清M-PLA2是一种急性期反应物。
