Aragno M, Tamagno E, Danni O, Ugazio G
Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Patologia Generale, Torino, Italy.
Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):341-54.
The effect of a single dose of carbon tetrachloride (CT), 1,2-dichloroethane (DCE) and the mixture on liver toxicity was investigated. The co-presence of both toxins exerts a more than additive effect on liver necrosis and on TBA-reactive substances produced by liver homogenates incubated at 37 degrees C. Both these effects are prevented in animals treated with vitamin E. The liver GSH is not involved in the synergistic action. The liver triglyceride levels of rats treated with the mixture are lower than in those treated with CT alone. This finding cannot be explained either by an improvement in the lipoprotein secretion or by the fact that the liver receives less NEFA. It is thus likely that the apparent protection against liver steatosis is the sign of more severe damage to the liver cell that partially blocks triglyceride synthesis. The mixture composed of CT+DCE exerts a potentiating action on liver toxicity with CT+DCE having the same characteristics as those, as previously reported, exerted by the co-presence of CT+DBE.
研究了单剂量四氯化碳（CT）、1,2 - 二氯乙烷（DCE）及其混合物对肝脏毒性的影响。两种毒素同时存在对肝脏坏死以及在37摄氏度孵育的肝脏匀浆产生的TBA反应性物质具有超过相加的作用。用维生素E处理的动物中这两种作用均被阻止。肝脏谷胱甘肽不参与协同作用。用混合物处理的大鼠肝脏甘油三酯水平低于单独用CT处理的大鼠。这一发现既不能通过脂蛋白分泌的改善来解释，也不能通过肝脏接受较少的非酯化脂肪酸这一事实来解释。因此，对肝脏脂肪变性的明显保护可能是肝细胞更严重损伤的迹象，这种损伤部分地阻断了甘油三酯的合成。由CT + DCE组成的混合物对肝脏毒性具有增强作用，CT + DCE具有与先前报道的CT + DBE同时存在时相同的特征。
