Haajanen Kati, Botting Nigel P
School of Chemistry, University of St. Andrews, St. Andrews, Fife, KY16 9ST Scotland, UK.
Steroids. 2006 Mar;71(3):231-9. doi: 10.1016/j.steroids.2005.10.005. Epub 2005 Dec 19.
Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hampered by the lack of suitable standards to allow accurate analysis. Herein, we report the syntheses of two racemic (13)C-labeled furofuran lignans [7,8,9-(13)C(3)]medioresinol and [7,8,9-(13)C(3)]sesamin as internal standards for LC-MS analysis. The labeled furofuran lignans were constructed from triply labeled cinnamyl alcohols, using a radical cyclization method.
植物木脂素目前正因其对人类健康的潜在益处而受到广泛研究，因为食用木脂素与降低患慢性疾病（如乳腺癌和冠心病）的风险相关。然而，对某些类别的木脂素，特别是呋喃并呋喃类木脂素的研究，因缺乏合适的标准品以进行准确分析而受到阻碍。在此，我们报告了两种外消旋的、用¹³C标记的呋喃并呋喃类木脂素[7,8,9-(¹³C)₃]中树脂醇和[7,8,9-(¹³C)₃]芝麻素的合成，作为液相色谱-质谱分析的内标物。标记的呋喃并呋喃类木脂素由三重标记的肉桂醇通过自由基环化方法构建而成。
