Koster Maranke I, Kim Soeun, Roop Dennis R
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
J Investig Dermatol Symp Proc. 2005 Nov;10(2):118-23. doi: 10.1111/j.1087-0024.2005.200416.x.
A critical role for p63 in the development of stratified epithelia, such as the epidermis, has been recognized since the generation of mice lacking p63 expression. The molecular role of p63 in epidermal morphogenesis, however, remained controversial. The epidermal phenotype of p63-/- mice, which are born with a single-layered surface epithelium instead of a fully stratified epidermis, suggested that p63 could have a role in stem cell maintenance or in the commitment to stratification. In this review, we discuss evidence suggesting that p63 is required for the commitment to stratification, making p63 the earliest known gene expressed in the developing epidermis that is specific for the keratinocyte lineage.
自从缺乏p63表达的小鼠产生以来，p63在分层上皮（如表皮）发育中的关键作用已得到认可。然而，p63在表皮形态发生中的分子作用仍存在争议。p63基因敲除小鼠出生时具有单层表面上皮而非完全分层的表皮，其表皮表型表明p63可能在干细胞维持或分层过程中发挥作用。在这篇综述中，我们讨论了相关证据，这些证据表明p63是分层过程所必需的，这使得p63成为发育中的表皮中最早已知的、对角质形成细胞谱系具有特异性的基因。
