Hutchinson M L, Agarwal P, Denault T, Berger B, Cibas E S
Department of Pathology, New England Medical Center, Boston, Massachusetts 02111.
Acta Cytol. 1992 Jul-Aug;36(4):499-504.
The objective of this study was to compare the sensitivity of a new test method with the smear method for detection of neoplasia of the uterine cervix. The new procedure, the ThinPrep process, is an automated, fluid-based technique for the collection and preparation of exfoliated and aspirated cytologic specimens. A single sample from each patient was split and prepared both with the smear and test methods. The diagnostic results from the two slides were compared in this blind study. Among a total of 2,655 patients, diagnoses concurred in 92% of cases and were within one diagnostic level of each other 98% of the time. The ThinPrep method facilitated the detection of more low-grade lesions (P less than .001, McNemar's test). In addition, the test method decreased the number of ambiguous interpretations. The ThinPrep method appears to improve the cervical cytologic smear quality by the harvest of a random and reproducible sample, with a reduction in artifacts. The new method improves the sensitivity of the cervical cytologic screening test.
本研究的目的是比较一种新的检测方法与涂片法对子宫颈肿瘤的检测敏感性。新方法即薄层液基制片法，是一种用于收集和制备脱落及吸出细胞学标本的自动化、基于液体的技术。从每位患者采集的单个样本被分开，分别用涂片法和检测法进行制备。在这项盲法研究中，对两张玻片的诊断结果进行了比较。在总共2655名患者中，92%的病例诊断结果一致，98%的时间内诊断结果在彼此的一个诊断级别范围内。薄层液基制片法有助于检测出更多的低级别病变（P小于0.001，McNemar检验）。此外，该检测方法减少了模糊解释的数量。薄层液基制片法似乎通过采集随机且可重复的样本提高了宫颈细胞学涂片质量，同时减少了人为假象。新方法提高了宫颈细胞学筛查检测的敏感性。
