Berry E M, Eisenberg S, Friedlander Y, Harats D, Kaufmann N A, Norman Y, Stein Y
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Am J Clin Nutr. 1992 Aug;56(2):394-403. doi: 10.1093/ajcn/56.2.394.
Seventeen male Yeshiva students were randomly allocated to a crossover study with two 12-wk dietary periods of monounsaturated fatty acids (MUFAs) vs a carbohydrate (CHO)-rich diet while concentrations of saturated (SFAs) and polyunsaturated (PUFAs) fatty acids were kept similar. Total plasma cholesterol (TC) decreased significantly by approximately 7.7% and low-density-lipoprotein cholesterol (LDL-C) by 14.4% on the MUFA diet, whereas on the CHO diet no significant change in cholesterol concentrations occurred, in contrast to that predicted by the equations of Keys and Hegsted. Concentrations of high-density-lipoprotein cholesterol (HDL-C) did not change significantly on either diet. On the MUFA diet there was a significantly lower proneness to peroxidation of plasma and LDL lipids and less extensive metabolism of conditioned LDL by peritoneal macrophages. We conclude that dietary MUFAs lower TC and LDL-C concentrations, independently of other dietary fatty acids and in addition may reduce the susceptibility of LDL to oxidative stress.
17名犹太神学院男学生被随机分配到一项交叉研究中，该研究包括两个为期12周的饮食阶段，分别是单不饱和脂肪酸（MUFA）饮食期和富含碳水化合物（CHO）的饮食期，同时保持饱和脂肪酸（SFA）和多不饱和脂肪酸（PUFA）的浓度相似。在MUFA饮食期间，总血浆胆固醇（TC）显著降低了约7.7%，低密度脂蛋白胆固醇（LDL-C）降低了14.4%，而在CHO饮食期间，胆固醇浓度没有显著变化，这与Keys和Hegsted方程预测的情况相反。两种饮食下高密度脂蛋白胆固醇（HDL-C）的浓度均无显著变化。在MUFA饮食中，血浆和LDL脂质过氧化的倾向显著降低，腹膜巨噬细胞对氧化型LDL的代谢也不那么广泛。我们得出结论，饮食中的MUFA可降低TC和LDL-C浓度，独立于其他膳食脂肪酸，此外还可能降低LDL对氧化应激的敏感性。
