Treacy P J, Jamieson G G, Dent J, Devitt P G, Heddle R
University Department of Surgery, Royal Adelaide Hospital, South Australia.
Am J Physiol. 1992 Jul;263(1 Pt 1):G1-5. doi: 10.1152/ajpgi.1992.263.1.G1.
We have investigated the role of ascending duodenal intramural nerves in the control of isolated pyloric pressure waves (IPPW) and liquid gastric emptying. In six pigs, the proximal duodenum was transected to interrupt intramural nerves. A further six pigs had a sham operation. Four weeks after operation, motility of the antrum, pylorus, and duodenum was recorded by side holes and a sleeve sensor. Gastric emptying of a 1,000-ml test meal was significantly more rapid in duodenum-transected animals (P less than 0.0001) during intraduodenal infusion of each of isosmolar dextrose (424 ml emptied), fatty acid (335 ml), and amino acids (396 ml) than in duodenum-intact animals (dextrose: 128 ml; fatty acid: 57 ml; amino acids: 192 ml). Associated with this, in duodenum-transected animals infusion of each of isosmolar dextrose, fatty acid, amino acids, and hyperosmolar saline failed to produce the stimulation of IPPW seen in duodenum-intact animals. In both duodenum-intact and -transected animals, supramaximal stimulation by intraduodenal infusion of 25% dextrose slowed gastric emptying and stimulated IPPW. Ascending duodenal intramural nerves are a major physiological pathway for nutrient- and osmolar-stimulated feedback control of pyloric motility and gastric emptying.
我们研究了十二指肠壁内上行神经在孤立幽门压力波（IPPW）控制和液体胃排空中的作用。在六头猪中，横断十二指肠近端以中断壁内神经。另有六头猪接受假手术。术后四周，通过侧孔和套管传感器记录胃窦、幽门和十二指肠的运动。在十二指肠内分别输注等渗葡萄糖（排空424毫升）、脂肪酸（335毫升）和氨基酸（396毫升）期间，横断十二指肠的动物胃排空1000毫升试验餐的速度明显快于十二指肠完整的动物（P<0.0001）（葡萄糖：十二指肠完整动物为128毫升；脂肪酸：57毫升；氨基酸：192毫升）。与此相关的是，在横断十二指肠的动物中，输注等渗葡萄糖、脂肪酸、氨基酸和高渗盐水均未能像十二指肠完整的动物那样刺激IPPW。在十二指肠完整和横断的动物中，十二指肠内输注25%葡萄糖进行超最大刺激均减缓了胃排空并刺激了IPPW。十二指肠壁内上行神经是营养物质和渗透压刺激的幽门运动及胃排空反馈控制的主要生理途径。
