Kojima J, Nakamura N, Kanatani M, Omori K
Cancer Res. 1975 Mar;35(3):542-7.
A method is proposed for the analysis of glycosaminoglycans that were isolated from human liver, combining cellulose acetate electrophoresis and enzymatic digestion with mucopolysaccharidases. The major constituent of glycossaminoglycans in the healthy liver is heparin sulfate and/or heparin (about 65%), with approximately equal quantities of dermatan sulfate and hyalauronic acid (about 13.5 and 13%, respectively) and a small amount of chondroitin sulfate. These components, especially chondroitin sulfate and hyaluronic acid, are markedly increased in hepatic carcinomas.
本文提出了一种分析从人肝脏中分离出的糖胺聚糖的方法，该方法结合了醋酸纤维素电泳和用粘多糖酶进行酶消化。健康肝脏中糖胺聚糖的主要成分是硫酸乙酰肝素和/或肝素（约65%），硫酸皮肤素和透明质酸的含量大致相等（分别约为13.5%和13%），还有少量硫酸软骨素。这些成分，尤其是硫酸软骨素和透明质酸，在肝癌中显著增加。
