Zharova E I, Sergeeva T I, Raushenbakh M O
Vopr Onkol. 1976;22(6):47-52.
45-day-old 229 mice of lines C57Bl and CC57Br were injected subcutaneously water solutions of tryptophan and thyrosine metabolites 2.5 mg twice a week, the total dosage being 45-50 mg per mouse. For the control mice of the same line were taken. Within the period from 3.5 to 19 months following injection of the metabolites in the urinary bladder of animals, there were observed focal proliferates of the epithelium not infrequently with its atypism, and also lymphoid infiltration of submucous and muscle layers, reticulosarcomas, papillomas, precancerous conditions and cancer. The question of the importance of endogenous blastomogenic substances in the development of "spontaneous" tumors of the urinary bladder in man is discussed.
给45日龄的229只C57Bl和CC57Br品系小鼠皮下注射色氨酸和酪氨酸代谢物的水溶液，剂量为2.5毫克，每周两次，每只小鼠的总剂量为45 - 50毫克。选取同品系的小鼠作为对照。在给动物注射代谢物后的3.5至19个月期间，观察到动物膀胱上皮出现局灶性增生，常伴有异型性，还出现了黏膜下层和肌层的淋巴样浸润、网状细胞肉瘤、乳头状瘤、癌前病变和癌症。文中讨论了内源性致瘤物质在人类膀胱“自发性”肿瘤发生发展中的重要性问题。
