Childs J E, Glass G E, Korch G W, Ksiazek T G, Leduc J W
Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland.
Am J Trop Med Hyg. 1992 Jul;47(1):27-34. doi: 10.4269/ajtmh.1992.47.27.
Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal.
1984年至1989年期间，主要从马里兰州巴尔的摩市的城市地点捕获了480只家鼠（小家鼠），并检测了它们对淋巴细胞性脉络丛脑膜炎病毒（LCMV）的抗体。大多数小鼠（95%）是在两个城市地点的住宅（n = 260）或城市公园（n = 196）中捕获的；另外还对五个地点进行了采样。总体而言，9.0%的小鼠LCMV抗体呈阳性，感染动物来自八个地点中的六个，包括所有三个主要城市地点，其患病率差异显著（3.9 - 13.4%）。患病率最高的地点是市中心的一个住宅地点，在街区和家庭中发现阳性小鼠明显聚集。在这个地点，LCMV抗体患病率也与各个街区内小鼠密度的估计值显著相关。家鼠中LCMV感染的聚集性可能是由于病毒的接触或垂直传播，以及小鼠高度结构化的社会系统，该系统促进近亲繁殖和有限的扩散。
