在果蝇胚胎和蛹翅中塑造骨形态发生蛋白形态发生素梯度。
Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing.
作者信息
O'Connor Michael B, Umulis David, Othmer Hans G, Blair Seth S
机构信息
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Development. 2006 Jan;133(2):183-93. doi: 10.1242/dev.02214.
Abstract
In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa. Likewise, during pupal wing development, BMPs help to specify vein versus intervein cell fate. Here, we review recent data suggesting that these two processes use a related set of extracellular factors, positive feedback, and BMP heterodimer formation to achieve peak levels of signaling in spatially restricted patterns. Because these signaling pathway components are all conserved, these observations should shed light on how BMP signaling is modulated in vertebrate development.
摘要
在早期果蝇胚胎中，BMP 型配体作为形态发生素发挥作用，抑制神经诱导并确定背侧外胚层和羊膜浆膜的形成。同样，在蛹翅发育过程中，BMP 有助于确定翅脉与翅脉间细胞的命运。在此，我们回顾近期的数据，这些数据表明这两个过程利用一组相关的细胞外因子、正反馈以及 BMP 异二聚体的形成，以在空间受限的模式中实现信号传导的峰值水平。由于这些信号通路成分都是保守的，这些观察结果应能阐明 BMP 信号在脊椎动物发育中是如何被调节的。
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本文引用的文献
1
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Annu Rev Genet. 2005;39:561-613. doi: 10.1146/annurev.genet.37.110801.143752.
2
The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing.无横脉基因编码了扭曲原肠胚形成家族中一种新的骨形态发生蛋白结合蛋白成员，该成员与短原肠胚形成蛋白一起，在果蝇翅膀的横脉中促进骨形态发生蛋白信号传导。
Dev Biol. 2005 Jun 1;282(1):70-83. doi: 10.1016/j.ydbio.2005.02.029.
3
Formation of the BMP activity gradient in the Drosophila embryo.果蝇胚胎中骨形态发生蛋白（BMP）活性梯度的形成。
Dev Cell. 2005 Jun;8(6):915-24. doi: 10.1016/j.devcel.2005.04.009.
4
Matching catalytic activity to developmental function: tolloid-related processes Sog in order to help specify the posterior crossvein in the Drosophila wing.使催化活性与发育功能相匹配：类Tolloid相关过程中，短 gastrulation 蛋白（Sog）有助于确定果蝇翅膀中的后横脉。
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