School of Life Sciences, University of Nevada, Las Vegas, NV 89154-4004, USA.
Curr Opin Cell Biol. 2012 Apr;24(2):158-65. doi: 10.1016/j.ceb.2011.11.004. Epub 2011 Dec 5.
Bone morphogenetic protein (BMP) signaling controls development and maintenance of many tissues. Genetic and quantitative approaches in Drosophila reveal that ligand isoforms show distinct function in wing development. Spatiotemporal control of BMP patterning depends on a network of extracellular proteins Pent, Ltl and Dally that regulate BMP signaling strength and morphogen range. BMP-mediated feedback regulation of Pent, Ltl, and Dally expression provides a system where cells actively respond to, and modify, the extracellular morphogen landscape to form a gradient that exhibits remarkable properties, including proportional scaling of BMP patterning with tissue size and the modulation of uniform tissue growth. This system provides valuable insights into mechanisms that mitigate the influence of variability to regulate cell-cell interactions and maintain organ function.
骨形态发生蛋白（BMP）信号通路控制着许多组织的发育和维持。果蝇中的遗传和定量方法表明，配体同工型在翅膀发育中表现出不同的功能。BMP 模式形成的时空控制取决于一系列细胞外蛋白 Pent、Ltl 和 Dally，它们调节 BMP 信号强度和形态发生素范围。BMP 对 Pent、Ltl 和 Dally 表达的反馈调节提供了一个系统，细胞可以主动响应并改变细胞外形态发生素景观，形成一个具有显著特性的梯度，包括 BMP 模式与组织大小的比例缩放和均匀组织生长的调节。这个系统为减轻变异性影响以调节细胞间相互作用和维持器官功能的机制提供了有价值的见解。
