低血液乙醇水平与创伤性损伤后老年小鼠细胞因子产生的改善有关。
A low blood ethanol level is associated with improved cytokine production in aged mice after traumatic injury.
作者信息
Plackett Timothy P, Jarrett Jennifer, Gamelli Richard L, Kovacs Elizabeth J
机构信息
Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Maywood, 60513, USA.
出版信息
J Trauma. 2005 Oct;59(4):984-9. doi: 10.1097/01.ta.0000174941.53688.01.
BACKGROUND
Many trauma patients have been consuming alcohol at the time of injury. Although high concentrations of alcohol are correlated with poor outcome, few studies have examined the effects of low levels of alcohol. We examined the effects of low alcohol exposure after burn injury using a murine model.
METHODS
Three- and 18-month-old mice were given ethanol or saline 30 minutes before a 15% total body surface area burn injury. Twenty-four hours after injury, cellular immune responses, including delayed-type hypersensitivity response and splenocyte proliferation were examined, along with production of interferon-gamma, interleukin (IL)-2, and IL-4.
RESULTS
Alcohol administration resulted in a significant increase in interferon-gamma in the aged, but not young, burn-injured mice. Likewise, slight increases in IL-2, IL-4, and the delayed-type hypersensitivity response were observed.
CONCLUSION
Low levels of ethanol at the time of injury are associated with partial restoration of immune responses in aged mice.
背景
许多创伤患者在受伤时饮酒。虽然高浓度酒精与不良预后相关，但很少有研究探讨低水平酒精的影响。我们使用小鼠模型研究了烧伤后低水平酒精暴露的影响。
方法
在15%体表面积烧伤前30分钟，给3个月和18个月大的小鼠给予乙醇或生理盐水。受伤24小时后，检测细胞免疫反应，包括迟发型超敏反应和脾细胞增殖，以及干扰素-γ、白细胞介素（IL）-2和IL-4的产生。
结果
在老年烧伤小鼠而非年轻烧伤小鼠中，给予酒精导致干扰素-γ显著增加。同样，观察到IL-2、IL-4和迟发型超敏反应略有增加。
结论
受伤时低水平乙醇与老年小鼠免疫反应的部分恢复有关。
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