Department of General Surgery, Tripler Army Medical Center, Honolulu, HI, USA.
J Am Coll Surg. 2010 Jan;210(1):73-8. doi: 10.1016/j.jamcollsurg.2009.09.019. Epub 2009 Oct 27.
Gender-specific differences have been found in the survival of patients after a burn injury. Using a murine model of burn injury, suppression of cell-mediated immunity occurs in a gender-specific manner. Immunosuppression correlated with elevated circulating interleukin-6. This study examines gender differences in cytokine production after injury and the role of interleukin-6.
A murine model of dorsal scald injury was used to examine differences in splenocyte production of interleukin-2, interleukin-4, and interferon-gamma in male versus female mice, and cytokine production in interleukin-6-deficient male mice.
At 24 hours after burn injury, there was substantially greater suppression of T-helper 1 cytokine production in male mice than in female mice. Interleukin-6-deficient male mice had improved cytokine production relative to wild-type mice.
Suppression of the cell-mediated immune response in male mice correlated with lower T-helper 1 cytokine production, compared with female mice. Additionally, immune response and cytokine production is improved by interleukin-6 deficiency.
在烧伤患者的生存中发现了性别特异性差异。使用烧伤损伤的小鼠模型，以性别特异性方式发生细胞介导的免疫抑制。免疫抑制与循环白细胞介素 6 的升高相关。本研究检查了损伤后细胞因子产生的性别差异和白细胞介素 6 的作用。
使用背部烫伤损伤的小鼠模型来检查雄性与雌性小鼠脾细胞产生白细胞介素 2、白细胞介素 4 和干扰素-γ的差异，以及白细胞介素 6 缺陷型雄性小鼠的细胞因子产生。
在烧伤后 24 小时，雄性小鼠中 T 辅助 1 细胞因子的产生受到明显更大的抑制，而雌性小鼠则受到抑制。白细胞介素 6 缺陷型雄性小鼠的细胞因子产生优于野生型小鼠。
与雌性小鼠相比，雄性小鼠细胞介导的免疫反应受到抑制，与 T 辅助 1 细胞因子产生降低相关。此外，白细胞介素 6 缺乏可改善免疫反应和细胞因子产生。
