Capasso G, Jaeger Ph, Robertson W G, Unwin R J
Research Center for Cardiovascular Diseases, Second University of Naples, Naples, Italy.
Curr Pharm Des. 2005;11(32):4153-9. doi: 10.2174/138161205774913219.
In this brief review and update, we try to cover recent developments in our understanding of uric acid transport by the kidney, the contribution of uric acid to renal stone disease, its potential role in progressive renal failure and, most recently, the novel and as yet unexplained link between the urinary glycoprotein Tamm-Horsfall protein (uromodulin) and hyperuricaemia and two inherited forms of renal disease with chronic renal failure.
在这篇简要的综述与更新中，我们试图涵盖近期在以下方面的进展：我们对肾脏尿酸转运的理解、尿酸对肾结石疾病的影响、其在进行性肾衰竭中的潜在作用，以及最近发现的、尚未得到解释的尿糖蛋白Tamm-Horsfall蛋白（尿调节蛋白）与高尿酸血症之间的新联系，还有两种伴有慢性肾衰竭的遗传性肾病。
