酰肼基氯化物作为新型双吡咯衍生物合成的前体。
Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives.
作者信息
Kheder Nabila Abdelshafy
机构信息
Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.
出版信息
Molecules. 2016 Mar 9;21(3):326. doi: 10.3390/molecules21030326.
Abstract
A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program.
摘要
描述了一种通过酰肼基卤化物方便地合成一些新型双吡咯衍生物的方法。对合成产物的一些选定实例进行了抗菌评估。具有氯取代基的双吡咯衍生物对所有使用的微生物均表现出良好的活性。通过分子操作环境（MOE）程序对双吡咯衍生物进行了分子对接。
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