Kadir S, Osinfade K, Lawal S O
Department of Medicine, University College Hopital, Ibadan.
West Afr J Med. 1992 Jan-Mar;11(1):79-81.
Symptomatic pericardial effusion (PE) occurred in two of our patients with chronic renal failure (CRF) who had taken minoxidil for control of their hypertension. One of them died from the effects of cardiogenic shock due to cardiac tamponade. The 2 patients had taken minoxidil for over 3 months. Other patients who had CRF had not developed symptomatic PE while being treated with other anti-hypertensive agents. Our experience conforms with reports from elsewhere that minoxidil may cause PE. Therefore, patients with CRF who need minoxidil as an anti-hypertensive agent should be examined regularly for clinical evidence of PE.
我们有两名慢性肾衰竭（CRF）患者在服用米诺地尔控制高血压时出现了有症状的心包积液（PE）。其中一人死于心脏压塞导致的心源性休克。这两名患者服用米诺地尔超过3个月。其他患有CRF的患者在使用其他抗高血压药物治疗时未出现有症状的PE。我们的经验与其他地方的报告一致，即米诺地尔可能会导致PE。因此，需要使用米诺地尔作为抗高血压药物的CRF患者应定期检查是否有PE的临床证据。
